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The Research To Cure PSC

Your donations to Children’s PSC Foundation have provided funding for numerous clinical studies and research related to PSC and oral vancomycin, including:    

Because Stanford has been the pioneer in oral vancomycin for PSC, we have worked closely with the team at Stanford over time.  However, in addition to continuing to work closely with and support the teams at Stanford, we continuously look for opportunities to outreach to other areas and other studies related to PSC, including internationally.

The current projects under discussion or underway that the Children’s PSC Foundation is supporting or planning to support include:

A double blind placebo controlled trial of oral vancomycin for PSC

  • A team in Milan, Italy, led by Dr. Marco Carbone as Primary Investigator, have developed a protocol for a randomized trial of oral vancomycin for PSC patients throughout Italy.

  • It is broadly agreed in the PSC community that a double blind placebo controlled trial is the best way to confirm the effectiveness of OV for PSC.

  • This work is extremely important to the PSC community and to the ability to achieve broad support for OV therapy for PSC.

  • Signficant tissue and serum analysis, as well as liver and biliary tree scans, will be done on the patients who enroll in this trial in order to better understand the mechanisms of impact of oral vancomycin.

  • The Children’s PSC Foundation has committed to provide funding for this trial.

A prospective clinical trial of Hymecromone for PSC

  • Stanford University, under leadership of co-Investigators Dr. Leina Alribadi and Dr. Aparna Goel, have developed a protocol for a clinical trial of Hymecromone as a potential immune system modulator to help address latent or ongoing inflammation and possible fibrosis in PSC patients.

  • The trial will combine Hymecromone with oral vancomycin, the existing standard of care therapy for PSC patients at Stanford, to track the impact of hymecromone on inflammation.

  • The Children’s PSC Foundation will provide funding to support this trial.

Other areas of interest that the Children’s PSC Foundation is exploring include:

  • Understanding the microbiome of PSC patients as compared to normal gut microbiota

  • The potential for microbiota transplant therapy (MMT) to restore the microbiome of PSC patients, possibly in combination with oral vancomycin therapy

  • The potential for MMT in combination with oral vancomycin and possibly a passive immune system modulator to resolve PSC

Research suggests that there are at least two elements at play in PSC: 1) a dysbiosis of the microbiome and 2) an auto-immune system response in the liver.  The likely combination of these two elements makes PSC complex, and both elements of PSC need further study.  

Our goal is to find a cure for PSC.  We believe the best path to achieve this goal is to support focused, targeted research and trials that will provide insights about PSC.  Ultimately, these insights will lead to better treatments and a cure.

Your contribution will make a difference in the lives of children living with Primary Sclerosing Cholangitis (PSC).  The Children's PSC Foundation is an all volunteer organization, and other than required, minor administration expenses all funds raised by the Children's PSC Foundation go directly to research.

Funds raised will support Primary Sclerosing Cholangitis (PSC) research. Your gift is tax deductible. Children’s PSC Foundation is a non-profit, tax-exempt entity pursuant to Section 501(c)3 Federal Tax ID # 26-4814733.

Support the Research

Your contribution will make a difference in the lives of children living with Primary Sclerosing Cholangitis (PSC).

Donate Now

Support the Research

Your contribution will make a difference in the lives of children living with Primary Sclerosing Cholangitis (PSC).

Donate Now